Effect of ivermectin on filariae of Mastomys natalensis.
Identifieur interne : 00DA32 ( Main/Exploration ); précédent : 00DA31; suivant : 00DA33Effect of ivermectin on filariae of Mastomys natalensis.
Auteurs : U R Rao [Inde] ; R. Chandrashekar ; D. SubrahmanyamSource :
- Parasitology research [ 0932-0113 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Brugia (), Dipetalonema (), Femelle, Filarioidea (), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filarioses (parasitologie), Filarioses (traitement médicamenteux), Infections à Dipetalonema (parasitologie), Infections à Dipetalonema (traitement médicamenteux), Ivermectine (pharmacologie), Ivermectine (usage thérapeutique), Microfilaria (), Muridae.
- MESH :
- parasitologie : Filariose lymphatique, Filarioses, Infections à Dipetalonema.
- pharmacologie : Ivermectine.
- traitement médicamenteux : Filariose lymphatique, Filarioses, Infections à Dipetalonema.
- usage thérapeutique : Ivermectine.
- Animaux, Brugia, Dipetalonema, Femelle, Filarioidea, Microfilaria, Muridae.
English descriptors
- KwdEn :
- Animals, Brugia (drug effects), Dipetalonema (drug effects), Dipetalonema Infections (drug therapy), Dipetalonema Infections (parasitology), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Filariasis (drug therapy), Filariasis (parasitology), Filarioidea (drug effects), Ivermectin (pharmacology), Ivermectin (therapeutic use), Microfilariae (drug effects), Muridae.
- MESH :
- chemical , pharmacology : Ivermectin.
- drug effects : Brugia, Dipetalonema, Filarioidea, Microfilariae.
- drug therapy : Dipetalonema Infections, Elephantiasis, Filarial, Filariasis.
- parasitology : Dipetalonema Infections, Elephantiasis, Filarial, Filariasis.
- chemical , therapeutic use : Ivermectin.
- Animals, Female, Muridae.
Abstract
The efficacy of ivermectin (Iv) was evaluated against four species of filariae, Litomosoides carinii, Acanthocheilonema viteae, Brugia pahangi and Brugia malayi in Mastomys natalensis. Animals with patent infections, induced with L3 larvae, by intravenous (iv) infusion of the respective microfilariae (Mf) (5 x 10(4) Mf per animal) or by intraperitoneal (ip) route (2 x 10(4) Mf per animal) were used in this study. A single dose of Iv (100 micrograms.kg-1) given subcutaneously (sc) to Mastomys infected with L. carinii or A. viteae resulted in the disappearance of microfilaremia within 2 h of treatment. Iv treatment of sc-infected animals with Brugia spp. had no immediate effect on the circulating Mf 60 days post-treatment. In contrast, such treatment of animals infected with Mf by intravenous infusion completely eliminated the larvae of all four species from the circulation. Iv treatment had no significant effect on the Mf of L. carinii, B. pahangi and B. malayi in animals infected by the ip route. However, the drug had dramatic effect in killing the Mf of A. viteae in the peritoneal cavity. Sera from Iv-treated normal or from L. carinii- or A. viteae-infected Mastomys were effective in clearing the circulating Mf of the species when administered to animals with the respective infections. Similar rapid clearance of Mf was seen when the sera were administered to animals infected iv with these larvae. Furthermore, adult females of L. carinii and A. viteae recovered from Mastomys on different days after Iv treatment released smaller numbers of Mf in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed: 2381895
Affiliations:
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Animals with patent infections, induced with L3 larvae, by intravenous (iv) infusion of the respective microfilariae (Mf) (5 x 10(4) Mf per animal) or by intraperitoneal (ip) route (2 x 10(4) Mf per animal) were used in this study. A single dose of Iv (100 micrograms.kg-1) given subcutaneously (sc) to Mastomys infected with L. carinii or A. viteae resulted in the disappearance of microfilaremia within 2 h of treatment. Iv treatment of sc-infected animals with Brugia spp. had no immediate effect on the circulating Mf 60 days post-treatment. In contrast, such treatment of animals infected with Mf by intravenous infusion completely eliminated the larvae of all four species from the circulation. Iv treatment had no significant effect on the Mf of L. carinii, B. pahangi and B. malayi in animals infected by the ip route. However, the drug had dramatic effect in killing the Mf of A. viteae in the peritoneal cavity. Sera from Iv-treated normal or from L. carinii- or A. viteae-infected Mastomys were effective in clearing the circulating Mf of the species when administered to animals with the respective infections. Similar rapid clearance of Mf was seen when the sera were administered to animals infected iv with these larvae. Furthermore, adult females of L. carinii and A. viteae recovered from Mastomys on different days after Iv treatment released smaller numbers of Mf in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Chandrashekar, R" sort="Chandrashekar, R" uniqKey="Chandrashekar R" first="R" last="Chandrashekar">R. Chandrashekar</name><name sortKey="Subrahmanyam, D" sort="Subrahmanyam, D" uniqKey="Subrahmanyam D" first="D" last="Subrahmanyam">D. Subrahmanyam</name></noCountry><country name="Inde"><noRegion><name sortKey="Rao, U R" sort="Rao, U R" uniqKey="Rao U" first="U R" last="Rao">U R Rao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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